Editorial Interstitial Lung Disease by Samantha J. Merck and Mary Armanios October 28, 2016. Over the past decade, it has become evident that abnormally short telomeres are a causal risk factor for pulmonary fibrosis in a large subset of patients. Mutations in the genes that code for the telomerase enzyme essential components are the most […]
Author: RepeatDx
Telomeres on Steroids – Turning Back the Mitotic Clock
Editorial in NEJM by Peter Lansdorp, M.D., Ph.D. May 19, 2016 In a study reported in The New England Journal of Medicine, Townsley et al. found that patients with diseases that are thought to result from defective telomere maintenance benefit from treatment with androgenic anabolic steroids.1 All 12 of the patients they examined had normalization […]
American Society of Hematology, 57th Annual Meeting, Orlando, FL December 5-8, 2015
Visit the Dyskeratosis Congenita Outreach at booth 2012 to learn more about Telomere Biology Disorders.
Long Telomere Length Associated with Increased Lung Cancer Risk
“The large-scale genetic study, conducted at the University of Chicago Medical Center, looked at the link between telomere length and risk for five common cancers. No significant associations between telomere length and other cancer types or subtypes were observed.” The findings were published in Human Molecular Genetics in July, 2015. Read more
Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study. Chenan Zhang, Jennifer A. Doherty, Stephen Burgess, et al. Human Molecular Genetics, 2015, 1–11
Age-associated telomere attrition of lymphocytes in vivo is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions. Lin Y, Damjanovic A, Metter EJ, Nguyen H,. et al. Clin Sci (Lond). 2015 Mar 1;128(6):367-77.
Telomere length in inherited bone marrow failure syndromes. Alter BP, Giri N, Savage SA, Rosenberg PS. Haematologica. 2015 Jan;100(1):49-54
Independent Study Finds Flow-fish Technique Superior as Performed by Repeat Diagnostics.
“In the clinical setting, flow-FISH was more accurate, reproducible, sensitive, and specific in the measurement of human leukocyte’s telomere length in comparison to qPCR.” Read more
4th Marrow Failure and Myelodysplasia Patient and Family Conference
Repeat Diagnostics is happy to sponsor this conference held at the Hospital for Sick Children in Toronto on October 26, 2014.