Team Telomere, in collaboration with RepeatDx, have just launched a brand-new video explaining telomere biology disorders. We are very pleased to be able to share with you the new Team Telomere video launched this week! The video runs through what telomeres are, what causes telomere biology disorders, what the symptoms can be and how they […]
Category: News
6-panel versus 2-panel telomere length tests
RepeatDx offers both 2- and 6-panel telomere length analysis tests, here we’ll take a look at the differences and what you should consider when determining which test to order. Telomere length analysis has emerged as an important diagnostic and screening tool for a range of telomere maintenance conditions including: Dyskeratosis congenita Pulmonary fibrosis Bone marrow […]
Dyskeratosis Congenita, Telomere Biology Disorders and the role of telomere length testing
Find out more about Dyskeratosis Congenita and Telomere Biology Disorders; what causes them, why the symptoms can vary and the importance of an accurate diagnosis. What is Dyskeratosis Congenita? Dyskeratosis Congenita (DC) is an inherited bone marrow failure syndrome that develops as a result of defective telomere maintenance. DC is therefore classed as a telomere […]
How Telomere Testing Is Being Used In Hospital Settings
Telomere testing is used as a diagnostic tool by medical professionals. When looking to find out about a patient’s health, this kind of test can reveal important information. While this type of testing is not yet widespread throughout the medical community, recent research published in PNAS has shown the rise and success of its use […]
Modified Instruments For Telomere Length Measurement
RepeatDx has received its second three-laser flow cytometer. Both instruments have been modified to achieve optimal telomere length measurements using our flow-FISH procedure. Our technologies available at RepeatDx are built to meet the increasing demand for telomere length measurement for clinical and other research studies. Recent publications have highlighted the role of telomere length measurement […]
Lymphocyte Homeostasis in Acquired Aplastic Anemia is Associated With Short Telomeres
Hepatitis‐associated aplastic anemia (HAA) is a variant of acquired aplastic anemia (AA) in which immune‐mediated bone marrow failure (BMF) develops following an acute episode of seronegative hepatitis. Dyskeratosis congenita (DC) is an inherited BMF syndrome characterized by the presence of short telomeres, mucocutaneous abnormalities, and cancer predisposition. While both conditions may cause BMF and hepatic […]
Shall we call them “telomere-mediated”? Renaming the idiopathic after the cause is found
Editorial Interstitial Lung Disease by Samantha J. Merck and Mary Armanios October 28, 2016. Over the past decade, it has become evident that abnormally short telomeres are a causal risk factor for pulmonary fibrosis in a large subset of patients. Mutations in the genes that code for the telomerase enzyme essential components are the most […]
Telomeres on Steroids – Turning Back the Mitotic Clock
Editorial in NEJM by Peter Lansdorp, M.D., Ph.D. May 19, 2016 In a study reported in The New England Journal of Medicine, Townsley et al. found that patients with diseases that are thought to result from defective telomere maintenance benefit from treatment with androgenic anabolic steroids.1 All 12 of the patients they examined had normalization […]
Long Telomere Length Associated with Increased Lung Cancer Risk
“The large-scale genetic study, conducted at the University of Chicago Medical Center, looked at the link between telomere length and risk for five common cancers. No significant associations between telomere length and other cancer types or subtypes were observed.” The findings were published in Human Molecular Genetics in July, 2015. Read more
Independent Study Finds Flow-fish Technique Superior as Performed by Repeat Diagnostics.
“In the clinical setting, flow-FISH was more accurate, reproducible, sensitive, and specific in the measurement of human leukocyte’s telomere length in comparison to qPCR.” Read more