Video: Techniques to measure telomere length

Flow FISH: measure telomere length

Accurately measuring telomere length is important for the diagnosis of telomere biology disorders, for research into how telomeres affect health span and aging, and their links to cancer. In this video we discuss a number of techniques to measure telomere length. Telomeres — the protective caps on the ends of our chromosomes — hold important […]

Video: Telomere Biology Disorders explained

Short telomeres and Telomere Biology Disorders explained

Telomere Biology Disorders (TBDs) are also known as Short Telomere Syndromes or telomeropathies. This video explores what causes TBDs and how they can impact people’s health. Telomere Biology Disorders (TBDs) are characterized by genetic deficits affecting telomere maintenance and by the presence of very short telomeres. Symptoms of TBDs can range significantly from person-to-person. In […]

Video: The links between telomerase and aging

Telomerase, aging and lengthening telomeres

The key to keeping our cells healthy may be down to the enzyme telomerase. In this video we cover how telomerase helps maintain telomere length in our cells, and how this influences how our bodies age, and why we develop diseases like cancer. Over time, with each cell division, telomeres shorten. When telomeres are too […]

Video: How telomere shortening affects aging

The End Replication problem and how it affects aging

Telomeres, in particular telomere length, have been shown to play a role in aging. In this video we explore how and why telomere shortening affects the aging process. Telomeres are unique structures of proteins and DNA, found on the ends of our chromosomes. Each time cells replicate, the number of DNA repeats making up our […]

How do telomeres affect cancer?

How do telomeres affect cancer?

Telomeres shorten as we age and the risk of cancer increases as we get older; here we explore some ways telomeres affect cancer risk. Cancer is a leading cause of death worldwide and with rates of many cancers increasing year on year, it is a priority research area in terms of improving understanding, diagnosis and […]

Telomeres and aging

Telomeres and aging blog

Telomere length is often considered a biological marker for aging and has been linked to cell lifespan, as well as certain diseases. Here we take a closer look at the relationship between telomeres and aging. What is a telomere? A telomere is a repetitive chain of DNA repeats found on the end of our chromosomes. […]

Why do telomeres shorten?

Why do telomeres shorten

Telomeres play an important role in protecting our chromosomes, but as we age, they decrease in length. In this blog we explore how and why telomeres shorten. Telomere structure Human telomeres are made up of thousands of repeats of the same DNA sequence (TTAGGG), bound by a special set of proteins called shelterin. They are […]

What are short telomeres?

What are short telomeres?

In this blog we examine what short telomeres are and what short telomere syndromes can mean for certain individuals.   What are telomeres for? Our chromosomes need to be protected to prevent damage, or them fusing with other chromosomes. Telomeres are the protective structures found on the end of chromosomes. They are made up of thousands […]